A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents.

Datta, Sandipan; Sahdeo, Sunil; Gray, Jennifer A; Morriseau, Christophe; Hammock, Bruce D; Cortopassi, Gino

Datta, Sandipan; Sahdeo, Sunil; Gray, Jennifer A; Morriseau, Christophe; Hammock, Bruce D; Cortopassi, Gino.

Afiliación

Datta S; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA.
Sahdeo S; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA.
Gray JA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA.
Morriseau C; Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Hammock BD; Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Cortopassi G; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, Davis, CA, 95616, USA. Electronic address: gcortopassi@ucdavis.edu.

Mitochondrion ; 31: 79-83, 2016 Nov.

Article en En | MEDLINE | ID: mdl-27717841

Asunto(s)

Técnicas Biosensibles/métodos; Contaminantes Ambientales/toxicidad; Ensayos Analíticos de Alto Rendimiento/métodos; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Toxicología/métodos; Línea Celular; Metabolismo Energético/efectos de los fármacos; Células Epiteliales/efectos de los fármacos; Células Epiteliales/fisiología; Humanos; Neuronas/efectos de los fármacos; Neuronas/fisiología; Desacopladores/toxicidad

Palabras clave

Bioenergetics; Biosensor; Cell-based assay; Environmental chemicals; High-throughput screening; Mitochondria; Oxygen; Toxicants

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxicología / Técnicas Biosensibles / Contaminantes Ambientales / Ensayos Analíticos de Alto Rendimiento / Mitocondrias Límite: Humans Idioma: En Revista: Mitochondrion Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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