Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres.

Zhu, Dong; Ye, Jing; Hu, Yue; Wen, Hong Mei; Kang, An; Tang, Yu-Ping; Chen, Jun; Shan, Chen Xiao; Cui, Xiao Bing

Zhu, Dong; Ye, Jing; Hu, Yue; Wen, Hong Mei; Kang, An; Tang, Yu-Ping; Chen, Jun; Shan, Chen Xiao; Cui, Xiao Bing.

Afiliación

Zhu D; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Ye J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Hu Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Wen HM; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Kang A; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Tang YP; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Chen J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Shan CX; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.
Cui XB; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. dongzhu@njucm.edu.cn yupingtang@njucm.edu.cn.

Chem Commun (Camb) ; 52(79): 11779-11782, 2016 Sep 27.

Article en En | MEDLINE | ID: mdl-27722615

ABSTRACT

ABSTRACT

A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.

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Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

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