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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of ß-secretase inhibitors.
Zuhl, Andrea M; Nolan, Charles E; Brodney, Michael A; Niessen, Sherry; Atchison, Kevin; Houle, Christopher; Karanian, David A; Ambroise, Claude; Brulet, Jeffrey W; Beck, Elizabeth M; Doran, Shawn D; O'Neill, Brian T; Am Ende, Christopher W; Chang, Cheng; Geoghegan, Kieran F; West, Graham M; Judkins, Joshua C; Hou, Xinjun; Riddell, David R; Johnson, Douglas S.
Afiliación
  • Zuhl AM; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • Nolan CE; Worldwide Medicinal Chemistry.
  • Brodney MA; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • Niessen S; Neuroscience Research Unit.
  • Atchison K; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • Houle C; Worldwide Medicinal Chemistry.
  • Karanian DA; Worldwide Medicinal Chemistry.
  • Ambroise C; Pfizer Worldwide Research and Development, San Diego, California 92121, USA.
  • Brulet JW; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • Beck EM; Neuroscience Research Unit.
  • Doran SD; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, USA.
  • O'Neill BT; Drug Safety Research and Development.
  • Am Ende CW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, USA.
  • Chang C; Drug Safety Research and Development.
  • Geoghegan KF; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • West GM; Neuroscience Research Unit.
  • Judkins JC; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • Hou X; Worldwide Medicinal Chemistry.
  • Riddell DR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
  • Johnson DS; Worldwide Medicinal Chemistry.
Nat Commun ; 7: 13042, 2016 10 11.
Article en En | MEDLINE | ID: mdl-27727204
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catepsina D / Pruebas de Toxicidad / Proteómica / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Ojo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catepsina D / Pruebas de Toxicidad / Proteómica / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Ojo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido