Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle.
J Cell Physiol
; 232(5): 958-966, 2017 05.
Article
en En
| MEDLINE
| ID: mdl-27736004
ABSTRACT
Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non-coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non-vesicular circulating miRNAs exhibit a potential role as mediators of the cross-talk between the skeletal muscle and other tissues/organs. In this review, we will focus on the emerging knowledge of miRNAs controlling mitochondrial function and insulin signaling in skeletal muscle cells. J. Cell. Physiol. 232 958-966, 2017. © 2016 Wiley Periodicals, Inc.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biogénesis de Organelos
/
Transducción de Señal
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Músculo Esquelético
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MicroARNs
/
Insulina
/
Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
J Cell Physiol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil