Analysis of morphine responses in mice reveals a QTL on Chromosome 7.

Crusio, Wim E; Dhawan, Esha; Chesler, Elissa J; Delprato, Anna

Crusio, Wim E; Dhawan, Esha; Chesler, Elissa J; Delprato, Anna.

Afiliación

Crusio WE; Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, University of Bordeaux, Pessac cedex, France; Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, CNRS, Pessac, France.
Dhawan E; Lambert High School, Suwanee, USA; BioScience Project, Wakefield, USA.
Chesler EJ; Jackson Laboratory, Bar Harbor, USA.
Delprato A; BioScience Project, Wakefield, USA.

F1000Res ; 5: 2156, 2016.

Article en En | MEDLINE | ID: mdl-27746909

ABSTRACT

ABSTRACT

In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.

Palabras clave

Locomotor activity; Opioids; QTL analysis; Reward pathway

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: F1000Res Año: 2016 Tipo del documento: Article País de afiliación: Francia