CD4 Count in HIV- Brain-Dead Donors: Insight into Donor Risk Assessment for HIV+ Donors.
Transplantation
; 101(4): 831-835, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-27748702
ABSTRACT
BACKGROUND:
The Human Immunodeficiency Virus (HIV) Organ Policy Equity Act allows for transplantation of organs from HIV-infected individuals (HIV+), provided it is performed under a research protocol. The safety assessment of an organ for transplantation is an essential element of the donation process. The risk for HIV-associated opportunistic infections increases as circulating CD4+ lymphocytes decrease to less than 200 cells/µL; however, the numbers of circulating CD4+ cells in the HIV-negative (HIV-) brain-dead donor (BDD) is not known.METHODS:
Circulating T-lymphocyte subset profiles in conventional HIV- BDD were measured in 20 BDD in a clinical laboratory.RESULTS:
The mean age of the BDD cohort was 48.7 years, 95% were white and 45% were women. The average body mass index was 29.2 kg/m. Cerebrovascular accident (40%) was the most prevalent cause of death. Sixteen (80%) subjects had a CD4 count ≤441 cells/µL (lower limit of normal) and 11 (55%) had a CD4 count less than 200 cells/µL; 11 (55%) subjects had a CD8 count ≤125 cells/µL (lower limit of normal). CD4/CD8 ratio was below normal in 3 patients (normal, 1.4-2.6). No recipient had a recognized donor-associated adverse event.CONCLUSIONS:
Absolute numbers of CD4 and CD8 T-lymphocytes are commonly reduced after brain death in HIV- individuals. Thus, CD4 absolute numbers are an inconsistent metric for assessing organ donor risk, irrespective of HIV status.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Donantes de Tejidos
/
Muerte Encefálica
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Infecciones por VIH
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Recuento de Linfocito CD4
/
Selección de Donante
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Guideline
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Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Transplantation
Año:
2017
Tipo del documento:
Article
País de afiliación:
Mongolia