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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).
Hamdouchi, Chafiq; Kahl, Steven D; Patel Lewis, Anjana; Cardona, Guemalli R; Zink, Richard W; Chen, Keyue; Eessalu, Thomas E; Ficorilli, James V; Marcelo, Marialuisa C; Otto, Keith A; Wilbur, Kelly L; Lineswala, Jayana P; Piper, Jared L; Coffey, D Scott; Sweetana, Stephanie A; Haas, Joseph V; Brooks, Dawn A; Pratt, Edward J; Belin, Ruth M; Deeg, Mark A; Ma, Xiaosu; Cannady, Ellen A; Johnson, Jason T; Yumibe, Nathan P; Chen, Qi; Maiti, Pranab; Montrose-Rafizadeh, Chahrzad; Chen, Yanyun; Reifel Miller, Anne.
Afiliación
  • Hamdouchi C; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Kahl SD; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Patel Lewis A; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Cardona GR; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Zink RW; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Chen K; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Eessalu TE; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Ficorilli JV; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Marcelo MC; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Otto KA; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Wilbur KL; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Lineswala JP; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Piper JL; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Coffey DS; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Sweetana SA; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Haas JV; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Brooks DA; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Pratt EJ; Eli Lilly and Company , 237994 Singapore.
  • Belin RM; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Deeg MA; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Ma X; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Cannady EA; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Johnson JT; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Yumibe NP; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Chen Q; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Maiti P; Jubilant Biosys Research Center , 560 022 Bangalore, India.
  • Montrose-Rafizadeh C; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Chen Y; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
  • Reifel Miller A; Lilly Research Laboratories, A division of Eli Lilly and Company , Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States.
J Med Chem ; 59(24): 10891-10916, 2016 12 22.
Article en En | MEDLINE | ID: mdl-27749056
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Compuestos de Espiro / Receptores Acoplados a Proteínas G / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Descubrimiento de Drogas / Hipoglucemiantes Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Compuestos de Espiro / Receptores Acoplados a Proteínas G / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Descubrimiento de Drogas / Hipoglucemiantes Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos