New isosorbide 5-mononitrate derivative with hypotensive activity.
Boll Chim Farm
; 128(2): 74-6, 1989 Feb.
Article
en En
| MEDLINE
| ID: mdl-2775521
Synthesis and pharmacological properties of the 5-fluoro-nicotinic ester with isosorbide-5-mononitrate 3 are reported. The new compound shows an in vitro activity on rabbit aortic helical strips five times higher than isosorbide-5-mononitrate. The hypotensive activity in guinea-pigs of 3 is markedly superior to that of 5-ISMN. In the rat 3 shows a bioavailability and an acute toxicity inferior to those of 5-ISMN after oral administration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dinitrato de Isosorbide
/
Antihipertensivos
Límite:
Animals
Idioma:
En
Revista:
Boll Chim Farm
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Italia