Lactam Triterpenoids from the Bark of Toona sinensis.
Nat Prod Bioprospect
; 6(5): 239-245, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27757925
ABSTRACT
Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities.
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Colección:
01-internacional
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MEDLINE
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En
Revista:
Nat Prod Bioprospect
Año:
2016
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Article