Effects of HDACi on Immunological Functions.
Methods Mol Biol
; 1510: 93-101, 2017.
Article
en En
| MEDLINE
| ID: mdl-27761815
ABSTRACT
Histone deacetylase inhibitors (HDACi) are used as therapeutics for several B cell-derived malignancies. Furthermore, they have been shown to modulate the response of the immune system, like the B cell function. HDACi treatment affects differentiation, proliferation, and survival of B cells. Here we describe how to investigate the effects of HDACi treatment on naïve B cells regarding class-switch recombination (CSR) in vitro using flow cytometry.
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Linfocitos B
/
Separación Inmunomagnética
/
Cambio de Clase de Inmunoglobulina
/
Inhibidores de Histona Desacetilasas
/
Histona Desacetilasas
Límite:
Animals
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Alemania