The Anticonvulsant Zonisamide Inhibits Hydroxyl Radical Generated from Methylguanidine.
Acta Med Okayama
; 70(5): 371-375, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27777429
ABSTRACT
Methylguanidine (MG) is a known nephrotoxin and neurotoxin, and an intracisternal injection of MG can induce convulsions in experimental animals. In this in vitro study, we examined the inhibitory effects of the antiepileptic agent zonisamide (ZNS) on hydroxyl radicals (â¢OH) generated from MG by using an electron spin resonance (ESR) technique. ZNS scavenged â¢OH generated from MG in a dose-dependent manner through direct scavenging during the auto-oxidation of MG. The rate constant of ZNS reacting with the â¢OH was at a near diffusion-controlled rate. These findings indicate that ZNS might detoxify MG and could thus protect against convulsive disorders.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Depuradores de Radicales Libres
/
Radical Hidroxilo
/
Isoxazoles
/
Metilguanidina
/
Anticonvulsivantes
Idioma:
En
Revista:
Acta Med Okayama
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón