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Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus.
Merlo, S; Novák, J; Tkácová, N; Nikolajevic Starcevic, J; Santl Letonja, M; Makuc, J; Cokan Vujkovac, A; Letonja, J; Bregar, D; Zorc, M; Rojko, M; Mankoc, S; Kruzliak, P; Petrovic, D.
Afiliación
  • Merlo S; Institute of Oncology Ljubljana, Zaloska 2, 1000 Ljubljana, Slovenia.
  • Tkácová N; Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, building A20, 625 00, Brno, Czech Republic.
  • Nikolajevic Starcevic J; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
  • Santl Letonja M; General Hospital Rakican, Ulica dr. Vrbnjaka 6, Murska Sobota, 9000, Slovenia.
  • Makuc J; General Hospital Slovenj Gradec, Gosposvetska cesta 1, 2380 Slovenj Gradec, Slovenia.
  • Cokan Vujkovac A; General Hospital Slovenj Gradec, Gosposvetska cesta 1, 2380 Slovenj Gradec, Slovenia.
  • Letonja J; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
  • Bregar D; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
  • Zorc M; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
  • Rojko M; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
  • Mankoc S; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
  • Kruzliak P; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne´s University Hospital and Masaryk University, Brno, Czech Republic.
  • Petrovic D; Institute of Histology and Embryology, Faculty of Medicine, University in Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
Balkan J Med Genet ; 18(2): 37-42, 2015 Dec 01.
Article en En | MEDLINE | ID: mdl-27785395
ABSTRACT
The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Balkan J Med Genet Año: 2015 Tipo del documento: Article País de afiliación: Eslovenia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Balkan J Med Genet Año: 2015 Tipo del documento: Article País de afiliación: Eslovenia