Genetics of Congenital Heart Disease: Past and Present.
Biochem Genet
; 55(2): 105-123, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-27807680
ABSTRACT
Congenital heart disease is the most common congenital anomaly, representing an important cause of infant morbidity and mortality. Congenital heart disease represents a group of heart anomalies that include septal defects, valve defects, and outflow tract anomalies. The exact genetic, epigenetic, or environmental basis of congenital heart disease remains poorly understood, although the exact mechanism is likely multifactorial. However, the development of new technologies including copy number variants, single-nucleotide polymorphism, next-generation sequencing are accelerating the detection of genetic causes of heart anomalies. Recent studies suggest a role of small non-coding RNAs, micro RNA, in congenital heart disease. The recently described epigenetic factors have also been found to contribute to cardiac morphogenesis. In this review, we present past and recent genetic discoveries in congenital heart disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
MicroARNs
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Organogénesis
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Epigénesis Genética
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Cardiopatías Congénitas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Genet
Año:
2017
Tipo del documento:
Article
País de afiliación:
Rumanía