Keeping it in check: chronic viral infection and antiviral immunity in the brain.
Nat Rev Neurosci
; 17(12): 766-776, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27811921
ABSTRACT
It is becoming clear that the manner by which the immune response resolves or contains infection by a pathogen varies according to the tissue that is affected. Unlike many peripheral cell types, CNS neurons are generally non-renewable. Thus, the cytolytic and inflammatory strategies that are effective in controlling infections in the periphery could be damaging if deployed in the CNS. Perhaps for this reason, the immune response to some CNS viral infections favours maintenance of neuronal integrity and non-neurolytic viral control. This modified immune response - when combined with the unique anatomy and physiology of the CNS - provides an ideal environment for the maintenance of viral genomes, including those of RNA viruses. Therefore, it is possible that such viruses can reactivate long after initial viral exposure, contributing to CNS disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Virus ARN
/
Virus ARN
/
Encéfalo
/
Inmunidad Innata
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos