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Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Wu, Yong-Jin; Guernon, Jason; Rajamani, Ramkumar; Toyn, Jeremy H; Ahlijanian, Michael K; Albright, Charles F; Muckelbauer, Jodi; Chang, ChiehYing; Camac, Dan; Macor, John E; Thompson, Lorin A.
Afiliación
  • Wu YJ; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address: Yong-Jin.Wu@bms.com.
  • Guernon J; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Rajamani R; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Toyn JH; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Ahlijanian MK; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Albright CF; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Muckelbauer J; Research and Development, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543, USA.
  • Chang C; Research and Development, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543, USA.
  • Camac D; Research and Development, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543, USA.
  • Macor JE; Research and Development, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543, USA.
  • Thompson LA; Research and Development, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.
Bioorg Med Chem Lett ; 26(23): 5729-5731, 2016 12 01.
Article en En | MEDLINE | ID: mdl-27816517
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazinas / Ácido Aspártico Endopeptidasas / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Furanos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazinas / Ácido Aspártico Endopeptidasas / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Furanos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido