Can Stopping Nerves, Stop Cancer?
Trends Neurosci
; 39(12): 880-889, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27832915
ABSTRACT
The nervous system is viewed as a tissue affected by cancer and as a conduit for the transmission of cancer pain and perineural invasion. Here, we review recent studies that indicate a more direct role. Several studies have shown that reducing stress or suppressing sympathetic drive correlates with improved outcomes and prolonged survival. Recent studies using animal models of visceral and somatic cancer further support a role for the nervous system in cancer progression. Specifically, nerve ablation had a profound impact on disease progression, including delayed development of precancerous lesions, and decreased tumor growth and metastasis. In this review, we summarize new evidence and discuss how future studies may address the role of neural signaling in the modulation of tumorigenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Neurosci
Año:
2016
Tipo del documento:
Article