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X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis.
Khalifa, Olfa; Pers, Yves-Marie; Ferreira, Rosanna; Sénéchal, Audrey; Jorgensen, Christian; Apparailly, Florence; Duroux-Richard, Isabelle.
Afiliación
  • Khalifa O; Inserm, U1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier, France. olfa.khalifa@inserm.fr.
  • Pers YM; University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France. olfa.khalifa@inserm.fr.
  • Ferreira R; Inserm, U1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier, France. ympers2000@yahoo.fr.
  • Sénéchal A; University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France. ympers2000@yahoo.fr.
  • Jorgensen C; Clinical Department for Osteoarticular Diseases and Biotherapy, University Hospital Lapeyronie, 34295 Montpellier, France. ympers2000@yahoo.fr.
  • Apparailly F; Clinical Department for Osteoarticular Diseases and Biotherapy, University Hospital Lapeyronie, 34295 Montpellier, France. rosannaferreiralopez@gmail.com.
  • Duroux-Richard I; Inserm, U1051, Institute for Neurosciences Montpellier, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier, France. audrey.senechal@inserm.fr.
Int J Mol Sci ; 17(11)2016 Nov 08.
Article en En | MEDLINE | ID: mdl-27834806
Rheumatoid arthritis (RA) is an autoimmune disease that predominantly affects women. MicroRNAs have emerged as crucial regulators of the immune system, whose expression is deregulated in RA. We aimed at quantifying the expression level of 14 miRNAs located on the X chromosome and at identifying whether differences are associated with disease and/or sex. A case-control study of 21 RA patients and 22 age- and sex-matched healthy controls was performed on peripheral blood mononuclear cells. The expression level of five miRNAs (miR-221, miR-222, miR-532, miR-106a, and miR-98) was significantly different between RA and controls when stratifying by sex, and the expression level of four miRNAs (miR-222, miR-532, miR-98, and miR-92a) was significantly different between RA females and males. The expression quantitative trait loci (eQTL) analysis revealed a significant gender effect of the FoxP3 promoter polymorphism rs3761548A/C on miR-221, miR-222 and miR-532 expression levels, and of the FoxP3 polymorphism rs2232365A/G on miR-221 expression levels in PBMC of RA patients. These data further support the involvement of the X chromosome in RA susceptibility. X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Cromosomas Humanos X / MicroARNs / Factores de Transcripción Forkhead Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Cromosomas Humanos X / MicroARNs / Factores de Transcripción Forkhead Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza