Primary Sjogren's syndrome presenting as hypokalemic paralysis: A case series.
J Postgrad Med
; 63(2): 128-131, 2017.
Article
en En
| MEDLINE
| ID: mdl-27853045
ABSTRACT
Primary Sjögren's syndrome (pSS) primarily involves exocrine glands, and renal tubular acidosis (RTA) is seen in one-third of the cases. RTA with hypokalemic paralysis as a presenting feature of pSS is described in few case reports in literature. We report 13 cases who presented as hypokalemic paralysis, and on evaluation were diagnosed to be pSS, as per the diagnostic criteria laid by the Sjögren's International Collaborative Clinical Alliance (2012). All patients were female, with a mean age at presentation being 33.1 ± 8.22 years (range, 25-48 years). Eleven patients had a complete distal RTA and two patients had incomplete distal RTA at the time of presentation. 62% (8/13) of patients had no signs and symptoms of exocrine gland involvement. All the cases were managed with oral alkali therapy, and six patients received additional immunomodulating agents. No improvement in renal tubular dysfunction (in the form of a reduction in the alkali dose) after immunomodulating therapy was observed over a mean follow-up of 2.8 years. Renal tubular dysfunction can be the presenting manifestation of pSS. It is important to consider the possible presence of this disorder in adults with otherwise unexplained distal RTA or hypokalemia.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parálisis
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Acidosis Tubular Renal
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Síndrome de Sjögren
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Hipopotasemia
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Postgrad Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
IN
/
INDIA
/
ÍNDIA