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Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification.
Blümcke, Ingmar; Aronica, Eleonora; Becker, Albert; Capper, David; Coras, Roland; Honavar, Mrinalini; Jacques, Thomas S; Kobow, Katja; Miyata, Hajime; Mühlebner, Angelika; Pimentel, José; Söylemezoglu, Figen; Thom, Maria.
Afiliación
  • Blümcke I; Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.
  • Aronica E; Department of NeuroPathology, Academic Medisch Centrum, Meibergdreef 9, 1105AZ Amsterdam, Netherlands.
  • Becker A; Department of Neuropathology, University of Bonn Medical Centre, Sigmund-Freud Str. 25, D - 53105 Bonn, Germany.
  • Capper D; Department of Neuropathology, Institute of Pathology, Im Neuenheimer Feld 224, 69120 Heidelberg, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
  • Coras R; Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.
  • Honavar M; Department of Anatomic Pathology, Hospital Pedro Hispano, Rua Dr Eduardo Torres, 4460-504 Matosinhos, Portugal.
  • Jacques TS; Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
  • Kobow K; Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.
  • Miyata H; Department of Neuropathology, Research Institute for Brain and Blood Vessels - AKITA, 6-10 Senshu-Kubota-Machi, Akita City, Akita 010-0874, Japan.
  • Mühlebner A; Department of NeuroPathology, Academic Medisch Centrum, Meibergdreef 9, 1105AZ Amsterdam, Netherlands.
  • Pimentel J; Laboratory of Neuropathology, Hospital de Santa Maria, (CHLN), Av. Prof. Egas Moniz, 1649-036, Lisbon, Portugal.
  • Söylemezoglu F; Department of Pathology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, TR-06100 Turkey.
  • Thom M; Department of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Nat Rev Neurol ; 12(12): 732-740, 2016 12.
Article en En | MEDLINE | ID: mdl-27857123
ABSTRACT
Rapid developments in molecular genetic technology and research have swiftly advanced our understanding of neuro-oncology. As a consequence, the WHO invited their expert panels to revise the current classification system of brain tumours and to introduce, for the first time, a molecular genetic approach for selected tumour entities, thus setting a new gold standard in histopathology. The revised 5th edition of the 'blue book' was released in May 2016 and will have a major impact in stratifying diagnosis and treatment. However, low-grade neuroepithelial tumours that present with early-onset focal epilepsy and are mostly seen in children and young adults (previously designated as long-term epilepsy-associated neuroepithelial tumours, LEAT) lack such innovative clinicopathological and molecular genetic tools. The Neuropathology Task Force of the International League against Epilepsy will critically discuss this issue, and will offer perspectives on how to decipher and validate clinically meaningful LEAT entities using the current WHO approach that integrates clinicopathological and genetic classification systems.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organización Mundial de la Salud / Neoplasias Encefálicas / Neoplasias Neuroepiteliales / Epilepsia Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Rev Neurol Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organización Mundial de la Salud / Neoplasias Encefálicas / Neoplasias Neuroepiteliales / Epilepsia Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Rev Neurol Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania