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Cytocompatible Polymer Grafting from Individual Living Cells by Atom-Transfer Radical Polymerization.
Kim, Ji Yup; Lee, Bong Soo; Choi, Jinsu; Kim, Beom Jin; Choi, Ji Yu; Kang, Sung Min; Yang, Sung Ho; Choi, Insung S.
Afiliación
  • Kim JY; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Korea.
  • Lee BS; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Korea.
  • Choi J; Department of Chemistry Education, Korea National University of Education, Chungbuk, 28173, Korea.
  • Kim BJ; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Korea.
  • Choi JY; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Korea.
  • Kang SM; Department of Chemistry, Chungbuk National University, Cheongju, 28644, Korea.
  • Yang SH; Department of Chemistry Education, Korea National University of Education, Chungbuk, 28173, Korea.
  • Choi IS; Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 34141, Korea.
Angew Chem Int Ed Engl ; 55(49): 15306-15309, 2016 12 05.
Article en En | MEDLINE | ID: mdl-27862790
A cytocompatible method of surface-initiated, activator regenerated by electron transfer, atom transfer radical polymerization (SI-ARGET ATRP) is developed for engineering cell surfaces with synthetic polymers. Dopamine-based ATRP initiators are used for both introducing the ATRP initiator onto chemically complex cell surfaces uniformly (by the material-independent coating property of polydopamine) and protecting the cells from radical attack during polymerization (by the radical-scavenging property of polydopamine). Synthetic polymers are grafted onto the surface of individual yeast cells without significant loss of cell viability, and the uniform and dense grafting is confirmed by various characterization methods including agglutination assay and cell-division studies. This work will provide a strategic approach to the generation of living cell-polymer hybrid structures and open the door to their application in multitude of areas, such as sensor technology, catalysis, theranostics, and cell therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Saccharomyces cerevisiae / Supervivencia Celular Idioma: En Revista: Angew Chem Int Ed Engl Año: 2016 Tipo del documento: Article Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Saccharomyces cerevisiae / Supervivencia Celular Idioma: En Revista: Angew Chem Int Ed Engl Año: 2016 Tipo del documento: Article Pais de publicación: Alemania