The 5-HT<sub>1A/1B</sub>-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity.

Korte, S Mechiel; Prins, Jolanda; Van den Bergh, Filip S; Oosting, Ronald S; Dupree, Rudy; Korte-Bouws, Gerdien A H; Westphal, Koen G C; Olivier, Berend; Denys, Damiaan A; Garland, Alexis; Güntürkün, Onur

The 5-HT_1A/1B-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity.

Korte, S Mechiel; Prins, Jolanda; Van den Bergh, Filip S; Oosting, Ronald S; Dupree, Rudy; Korte-Bouws, Gerdien A H; Westphal, Koen G C; Olivier, Berend; Denys, Damiaan A; Garland, Alexis; Güntürkün, Onur.

Afiliación

Korte SM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands; Department of Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr-University Bochum, Germany. Electronic address: s.m.korte@uu.nl.
Prins J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands.
Van den Bergh FS; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands.
Oosting RS; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands.
Dupree R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands.
Korte-Bouws GA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands.
Westphal KG; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University, The Netherlands.
Olivier B; Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands.
Denys DA; Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands.
Garland A; Department of Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr-University Bochum, Germany.
Güntürkün O; Department of Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr-University Bochum, Germany.

Eur J Pharmacol ; 794: 257-269, 2017 Jan 05.

Article en En | MEDLINE | ID: mdl-27866999

Asunto(s)

Dopamina/metabolismo; Conducta Impulsiva/efectos de los fármacos; Motivación/efectos de los fármacos; Núcleo Accumbens/efectos de los fármacos; Piperazinas/farmacología; Corteza Prefrontal/efectos de los fármacos; Agonistas del Receptor de Serotonina 5-HT1/farmacología; Animales; Conducta de Elección/efectos de los fármacos; Masculino; Núcleo Accumbens/metabolismo; Corteza Prefrontal/metabolismo; Ratas; Receptor de Serotonina 5-HT1A/metabolismo; Receptor de Serotonina 5-HT1B/metabolismo; Recompensa

Palabras clave

5-HT(1A/1B)-receptor; Eltoprazine; Eltoprazine (PubChem CID: 65853); Impulsivity; Microdialysis; Monoamines; Prefrontal cortex

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Dopamina / Corteza Prefrontal / Agonistas del Receptor de Serotonina 5-HT1 / Conducta Impulsiva / Motivación / Núcleo Accumbens Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos

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