Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle.
Exp Cell Res
; 350(1): 184-189, 2017 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-27890645
ABSTRACT
The human endometrium is a highly dynamic tissue with the ability to cyclically regenerate during the reproductive life. Endometrial mesenchymal stem-like cells (eMSCs) located throughout the endometrium have shown to functionally contribute to endometrial regeneration. In this study we examine whether the menstrual cycle stage and the location in the endometrial bilayer (superficial and deep portions of the endometrium) has an effect on stem cell activities of eMSCs (CD140b+CD146+ cells). Here we show the percentage and clonogenic ability of eMSCs were constant in the various stages of the menstrual cycle (menstrual, proliferative and secretory). However, eMSCs from the menstrual endometrium underwent significantly more rounds of self-renewal and enabled a greater total cell output than those from the secretory phase. Significantly more eMSCs were detected in the deeper portion of the endometrium compared to the superficial layer but their clonogenic and self-renewal activities remained similar. Our findings suggest that eMSCs are activated in the menstrual phase for the cyclical regeneration of the endometrium.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endometrio
/
Células Madre Mesenquimatosas
/
Ciclo Menstrual
Límite:
Female
/
Humans
Idioma:
En
Revista:
Exp Cell Res
Año:
2017
Tipo del documento:
Article
País de afiliación:
China