The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity.
Clin Neurophysiol
; 128(1): 176-182, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-27912171
ABSTRACT
OBJECTIVE:
Up to 30% of people with juvenile myoclonic epilepsy (JME) have photoparoxysmal responses (PPR). Recent studies report on structural and pathophysiological differences between people with JME with (JME+PPR) and without PPR (JME-PPR). We investigated whether electrophysiological features outside photic stimulation differ between these subtypes.METHODS:
We analysed EEG recordings of people with JME at a tertiary epilepsy centre and an academic hospital. Photosensitivity was assessed in a drug-naïve condition. We compared the occurrence and involvement of posterior electrodes for focal abnormalities and generalised spike-wave activity in the EEG outside photic stimulation between JME+PPR and JME-PPR.RESULTS:
We included EEG recordings of 18 people with JME+PPR and 21 with JME-PPR. People with JME-PPR had less focal abnormalities in the posterior brain regions than people with JME+PPR (19% vs 55%, p<0.05). There was no difference in the distribution of generalised spike-wave activity between people with JME+PPR and JME-PPR.CONCLUSION:
This study demonstrates electrophysiological correlates of the previously described structural and physiological differences between JME+PPR and JME-PPR.SIGNIFICANCE:
Findings support the hypothesis that posterior interictal EEG abnormalities reflect localised cortical hyperexcitability, which makes patients with JME more sensitive to photic stimuli.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estimulación Luminosa
/
Mapeo Encefálico
/
Potenciales de Acción
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Epilepsia Mioclónica Juvenil
/
Epilepsia Refleja
/
Electroencefalografía
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
/
Male
Idioma:
En
Revista:
Clin Neurophysiol
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2017
Tipo del documento:
Article