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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models.
Beaumont, Vahri; Zhong, Sheng; Lin, Hai; Xu, WenJin; Bradaia, Amyaouch; Steidl, Esther; Gleyzes, Melanie; Wadel, Kristian; Buisson, Bruno; Padovan-Neto, Fernando E; Chakroborty, Shreaya; Ward, Karen M; Harms, John F; Beltran, Jose; Kwan, Mei; Ghavami, Afshin; Häggkvist, Jenny; Tóth, Miklós; Halldin, Christer; Varrone, Andrea; Schaab, Christoph; Dybowski, J Nikolaj; Elschenbroich, Sarah; Lehtimäki, Kimmo; Heikkinen, Taneli; Park, Larry; Rosinski, James; Mrzljak, Ladislav; Lavery, Daniel; West, Anthony R; Schmidt, Christopher J; Zaleska, Margaret M; Munoz-Sanjuan, Ignacio.
Afiliación
  • Beaumont V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, CA 90045, USA. Electronic address: vahri.beaumont@chdifoundation.org.
  • Zhong S; Psychogenics Inc., 100 Philips Parkway, Montvale, NJ 07645, USA.
  • Lin H; Psychogenics Inc., 100 Philips Parkway, Montvale, NJ 07645, USA.
  • Xu W; Psychogenics Inc., 100 Philips Parkway, Montvale, NJ 07645, USA.
  • Bradaia A; Neuroservice, Domaine Saint Hilaire, CS30531, 595 rue Pierre BERTHIER, 13593 Aix-en-Provence Cedex 3, France.
  • Steidl E; Neuroservice, Domaine Saint Hilaire, CS30531, 595 rue Pierre BERTHIER, 13593 Aix-en-Provence Cedex 3, France.
  • Gleyzes M; Neuroservice, Domaine Saint Hilaire, CS30531, 595 rue Pierre BERTHIER, 13593 Aix-en-Provence Cedex 3, France.
  • Wadel K; Neuroservice, Domaine Saint Hilaire, CS30531, 595 rue Pierre BERTHIER, 13593 Aix-en-Provence Cedex 3, France.
  • Buisson B; Neuroservice, Domaine Saint Hilaire, CS30531, 595 rue Pierre BERTHIER, 13593 Aix-en-Provence Cedex 3, France.
  • Padovan-Neto FE; Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
  • Chakroborty S; Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
  • Ward KM; Neuroscience Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Harms JF; Neuroscience Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Beltran J; Psychogenics Inc., 100 Philips Parkway, Montvale, NJ 07645, USA.
  • Kwan M; Psychogenics Inc., 100 Philips Parkway, Montvale, NJ 07645, USA.
  • Ghavami A; Psychogenics Inc., 100 Philips Parkway, Montvale, NJ 07645, USA.
  • Häggkvist J; Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatry Research, R5:02, Karolinska University Hospital, 17176 Stockholm, Sweden.
  • Tóth M; Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatry Research, R5:02, Karolinska University Hospital, 17176 Stockholm, Sweden.
  • Halldin C; Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatry Research, R5:02, Karolinska University Hospital, 17176 Stockholm, Sweden.
  • Varrone A; Department of Clinical Neuroscience, Karolinska Institutet, Centre for Psychiatry Research, R5:02, Karolinska University Hospital, 17176 Stockholm, Sweden.
  • Schaab C; Evotec (München) GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany.
  • Dybowski JN; Evotec (München) GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany.
  • Elschenbroich S; Evotec (München) GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany.
  • Lehtimäki K; Charles River Discovery, Microkatu 1, 70210 Kuopio, Finland.
  • Heikkinen T; Charles River Discovery, Microkatu 1, 70210 Kuopio, Finland.
  • Park L; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, CA 90045, USA.
  • Rosinski J; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, CA 90045, USA.
  • Mrzljak L; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, CA 90045, USA.
  • Lavery D; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, CA 90045, USA.
  • West AR; Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
  • Schmidt CJ; Neuroscience Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Zaleska MM; Neuroscience Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Munoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, CA 90045, USA.
Neuron ; 92(6): 1220-1237, 2016 Dec 21.
Article en En | MEDLINE | ID: mdl-27916455
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Pirazoles / Quinolinas / Corteza Cerebral / Neostriado / Enfermedad de Huntington Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Pirazoles / Quinolinas / Corteza Cerebral / Neostriado / Enfermedad de Huntington Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos