Total synthesis of (±)-naphthacemycin A<sub>9</sub>, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of ß-lactam resistance.

Hirose, Tomoyasu; Kojima, Yasuhiro; Matsui, Hidehito; Hanaki, Hideaki; Iwatsuki, Masato; Shiomi, Kazuro; Omura, Satoshi; Sunazuka, Toshiaki

Total synthesis of (±)-naphthacemycin A₉, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of ß-lactam resistance.

Hirose, Tomoyasu; Kojima, Yasuhiro; Matsui, Hidehito; Hanaki, Hideaki; Iwatsuki, Masato; Shiomi, Kazuro; Omura, Satoshi; Sunazuka, Toshiaki.

Afiliación

Hirose T; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Kojima Y; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Matsui H; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Hanaki H; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Iwatsuki M; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Shiomi K; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Omura S; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Sunazuka T; Graduate School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.

J Antibiot (Tokyo) ; 70(5): 574-581, 2017 May.

Article en En | MEDLINE | ID: mdl-27924114

Asunto(s)

Antibacterianos/farmacología; Enterococcus/efectos de los fármacos; Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos; Naftacenos/farmacología; Antibacterianos/síntesis química; Antibacterianos/química; Naftacenos/síntesis química; Naftacenos/química; Relación Estructura-Actividad; Resistencia a la Vancomicina; Resistencia betalactámica; beta-Lactamas/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterococcus / Staphylococcus aureus Resistente a Meticilina / Antibacterianos / Naftacenos Idioma: En Revista: J Antibiot (Tokyo) Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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