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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach.
Snelder, Nelleke; Ploeger, Bart A; Luttringer, Olivier; Rigel, Dean F; Webb, Randy L; Feldman, David; Fu, Fumin; Beil, Michael; Jin, Liang; Stanski, Donald R; Danhof, Meindert.
Afiliación
  • Snelder N; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Ploeger BA; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Luttringer O; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Rigel DF; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Webb RL; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Feldman D; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Fu F; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Beil M; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Jin L; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Stanski DR; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
  • Danhof M; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands (N.S., B.A.P., M.D.); LAP&P Consultants BV, Leiden, The Netherlands (N.S., M.D.); Modeling and Simulation Department, Novartis, Basel, Switzerland (O.L., D.R.S.); Cardiovascular and Metabolism Research, N
J Pharmacol Exp Ther ; 360(2): 356-367, 2017 02.
Article en En | MEDLINE | ID: mdl-27934627
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azetidinas / Compuestos de Bencilo / Sistema Cardiovascular / Clorhidrato de Fingolimod / Modelos Biológicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Pharmacol Exp Ther Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azetidinas / Compuestos de Bencilo / Sistema Cardiovascular / Clorhidrato de Fingolimod / Modelos Biológicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Pharmacol Exp Ther Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos