Minimally Toxic Dose of Lipopolysaccharide and &#945;-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation.

Zhang, Wei; Gao, Jun-Hua; Yan, Zhao-Fen; Huang, Xi-Yan; Guo, Peng; Sun, Li; Liu, Zhuo; Hu, Yang; Zuo, Li-Jun; Yu, Shu-Yang; Cao, Chen-Jie; Wang, Xiao-Min; Hong, Jau-Shyong

Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation.

Zhang, Wei; Gao, Jun-Hua; Yan, Zhao-Fen; Huang, Xi-Yan; Guo, Peng; Sun, Li; Liu, Zhuo; Hu, Yang; Zuo, Li-Jun; Yu, Shu-Yang; Cao, Chen-Jie; Wang, Xiao-Min; Hong, Jau-Shyong.

Afiliación

Zhang W; Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. ttyyzw@163.com.
Gao JH; Department of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China. ttyyzw@163.com.
Yan ZF; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China. ttyyzw@163.com.
Huang XY; Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Beijing, 100069, China. ttyyzw@163.com.
Guo P; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, 100069, China. ttyyzw@163.com.
Sun L; Beijing Key Laboratory on Parkinson's Disease, Beijing, 100053, China. ttyyzw@163.com.
Liu Z; Department of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Hu Y; Department of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Zuo LJ; Department of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Yu SY; Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Cao CJ; Department of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Wang XM; Department of Neurology, Beijing Tiantian Hospital, Capital Medical University, Beijing, 100050, China.
Hong JS; Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

Mol Neurobiol ; 55(1): 619-632, 2018 01.

Article en En | MEDLINE | ID: mdl-27975175

Asunto(s)

Neuronas Dopaminérgicas/patología; Lipopolisacáridos/toxicidad; Microglía/enzimología; NADPH Oxidasa 2/metabolismo; Degeneración Nerviosa/patología; alfa-Sinucleína/toxicidad; Animales; Membrana Celular/efectos de los fármacos; Membrana Celular/metabolismo; Neuronas Dopaminérgicas/efectos de los fármacos; Neuronas Dopaminérgicas/metabolismo; Activación Enzimática/efectos de los fármacos; Ratones Endogámicos C57BL; Microglía/efectos de los fármacos; NADPH Oxidasa 2/antagonistas & inhibidores; NADPH Oxidasa 2/deficiencia; Degeneración Nerviosa/metabolismo; Neuroprotección/efectos de los fármacos; Neurotoxinas/toxicidad; Subunidades de Proteína/metabolismo; Ratas Sprague-Dawley; Transducción de Señal/efectos de los fármacos

Palabras clave

Dopaminergic neurodegeneration; Environmental factors; Lipopolysaccharide; Microglial activation; Parkinson disease; Synergistic; α-Synuclein oligomer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Microglía / Alfa-Sinucleína / Neuronas Dopaminérgicas / NADPH Oxidasa 2 / Degeneración Nerviosa Límite: Animals Idioma: En Revista: Mol Neurobiol Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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