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Distinct cellular and molecular environments support aging-related DNA methylation changes in the substantia nigra.
Fasolino, Maria; Liu, Shuo; Wang, Yinsheng; Zhou, Zhaolan.
Afiliación
  • Fasolino M; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Liu S; Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA.
  • Wang Y; Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA.
  • Zhou Z; Department of Chemistry, University of California, Riverside, CA 92521, USA.
Epigenomics ; 9(1): 21-31, 2017 01.
Article en En | MEDLINE | ID: mdl-27981856
AIM: We aimed to couple brain region-specific changes in global DNA methylation over aging to underlying cellular and molecular environments. MATERIALS & METHODS: We measured two major forms of DNA methylation and analyzed Dnmt, Tet and metabolite levels in the striatum and substantia nigra (SN) over aging in healthy male mice. RESULTS: The ratio of 5-hydroxymethylcytosine to 5-methylcytosine increases over aging in the SN, and 5-hydroxymethylcytosine increases preferentially in dopaminergic neurons. Additionally, this age-dependent alteration in methylation correlates with a reduction in the ratio of α-ketoglutarate to succinate in the SN. CONCLUSION: Distinct cellular and molecular environments correlate with aging-associated methylation changes in the SN, implicating this epigenetic mechanism in the susceptibility of this brain region to age-related cell loss.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Sustancia Negra / Metilación de ADN Límite: Animals Idioma: En Revista: Epigenomics Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Sustancia Negra / Metilación de ADN Límite: Animals Idioma: En Revista: Epigenomics Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido