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Paraneoplastic cerebellar degeneration and lambert-eaton myasthenia in a patient with merkel cell carcinoma and voltage-gated calcium channel antibodies.
Pavolucci, Lucia; Giannini, Giulia; Giannoccaro, Maria Pia; Foschini, Maria Pia; Lang, Bethan; Avoni, Patrizia; Tinuper, Paolo; Vincent, Angela; Liguori, Rocco.
Afiliación
  • Pavolucci L; Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Via Altura 3, 40139, Bologna, Italy.
  • Giannini G; Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Via Altura 3, 40139, Bologna, Italy.
  • Giannoccaro MP; Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Via Altura 3, 40139, Bologna, Italy.
  • Foschini MP; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
  • Lang B; Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Via Altura 3, 40139, Bologna, Italy.
  • Avoni P; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
  • Tinuper P; Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Via Altura 3, 40139, Bologna, Italy.
  • Vincent A; IRCCS Institute of Neurological Sciences, Bologna, Italy.
  • Liguori R; Department of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Via Altura 3, 40139, Bologna, Italy.
Muscle Nerve ; 56(5): 998-1000, 2017 Nov.
Article en En | MEDLINE | ID: mdl-28006860
INTRODUCTION: Merkel cell carcinoma is a rare cutaneous, aggressive tumor. Although it shares many neuroendocrine features with small cell lung carcinoma, it has only occasionally been reported with paraneoplastic neurological syndromes. METHODS: A healthy 67-year-old man developed acute ataxia, vertigo, and nausea. Subsequently he also developed dysarthria, diplopia, xerostomia, fatigability and progressive anorexia. He underwent a full diagnostic workup and was found to have a high titer of voltage-gated calcium channel antibodies in serum and cerebrospinal fluid, neurophysiological findings compatible with Lambert-Eaton myasthenia and neurological signs compatible with cerebellar degeneration. RESULTS: A positron emission tomography study revealed a hypermetabolic lesion in the axilla, subsequently biopsied and consistent with Merkel cell carcinoma. CONCLUSIONS: In most previous reports, neurological symptoms preceded the Merkel cell carcinoma diagnosis, and the primary localization was in lymph nodes. This tumor should be considered in patients with paraneoplastic syndrome, and particularly Lambert-Eaton myasthenia after exclusion of small cell lung carcinoma. Muscle Nerve 56: 998-1000, 2017.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Carcinoma de Células de Merkel / Síndrome Miasténico de Lambert-Eaton / Degeneración Cerebelosa Paraneoplásica / Canales de Calcio Tipo N / Neoplasias Pulmonares Límite: Aged / Humans / Male Idioma: En Revista: Muscle Nerve Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Carcinoma de Células de Merkel / Síndrome Miasténico de Lambert-Eaton / Degeneración Cerebelosa Paraneoplásica / Canales de Calcio Tipo N / Neoplasias Pulmonares Límite: Aged / Humans / Male Idioma: En Revista: Muscle Nerve Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos