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Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis.
Varhaug, Kristin N; Vedeler, Christian A; Myhr, Kjell-Morten; Aarseth, Jan Harald; Tzoulis, Charalampos; Bindoff, Laurence A.
Afiliación
  • Varhaug KN; Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
  • Vedeler CA; Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
  • Myhr KM; Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Norwegian MS-Registry & Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of C
  • Aarseth JH; KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Norwegian MS-Registry & Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
  • Tzoulis C; Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
  • Bindoff LA; Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway. Electronic address: laurence.bindoff@nevro.uib.no.
Mitochondrion ; 34: 32-35, 2017 05.
Article en En | MEDLINE | ID: mdl-28017684
Mitochondrial DNA (mtDNA) can act as damage-associated molecular pattern molecule (DAMP) and initiate an inflammatory response. We hypothesized that the concentration of mtDNA might reflect inflammatory activity in multiple sclerosis and investigated therefore levels of cell-free mitochondrial DNA in cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis. Significantly higher levels of mtDNA were found in patients compared to controls and there was an inverse correlation between disease duration and mtDNA concentration. Our study suggests that mitochondria can be involved early in multiple sclerosis, but whether this is as an initiator of the inflammatory response or part of its maintenance is unclear. Further, our study suggests that changes in mtDNA may provide a novel marker for early disease activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Mitocondrial / Líquido Cefalorraquídeo / Esclerosis Múltiple Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mitochondrion Año: 2017 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Mitocondrial / Líquido Cefalorraquídeo / Esclerosis Múltiple Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mitochondrion Año: 2017 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Países Bajos