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Spongian-16-one Diterpenes and Their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi.
Forster, Louise C; Winters, Anne E; Cheney, Karen L; Dewapriya, Pradeep; Capon, Robert J; Garson, Mary J.
Afiliación
  • Forster LC; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
  • Winters AE; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
  • Cheney KL; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
  • Dewapriya P; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
  • Capon RJ; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
  • Garson MJ; School of Chemistry and Molecular Biosciences, ‡School of Biological Sciences, and §Institute for Molecular Bioscience, The University of Queensland , Brisbane, QLD 4072, Australia.
J Nat Prod ; 80(3): 670-675, 2017 03 24.
Article en En | MEDLINE | ID: mdl-28032760
ABSTRACT
Six new (1-6) spongian-16-one analogues have been characterized from the Australian nudibranch species Goniobranchus collingwoodi, along with four known spongian-16-one derivatives. The structures and relative configuration were suggested by spectroscopic analyses informed by molecular modeling. Dissection of animal tissue revealed that the mantle and viscera differ in their terpene composition. Whole body extracts were not toxic to brine shrimp (Artemia sp.), but were unpalatable to palaemon shrimp (Palaemon serenus) at a concentration found within the nudibranch. Individual terpenes were not cytotoxic to human lung (NCIH-460), colorectal (SW620), and liver (HepG2) cancer cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diterpenos / Gastrópodos / Antineoplásicos Límite: Animals / Humans País/Región como asunto: Oceania Idioma: En Revista: J Nat Prod Año: 2017 Tipo del documento: Article País de afiliación: Australia
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diterpenos / Gastrópodos / Antineoplásicos Límite: Animals / Humans País/Región como asunto: Oceania Idioma: En Revista: J Nat Prod Año: 2017 Tipo del documento: Article País de afiliación: Australia