Reversible control of solubility using functionalized nanoparticles.
Chem Commun (Camb)
; 53(8): 1429-1432, 2017 Jan 24.
Article
en En
| MEDLINE
| ID: mdl-28079205
ABSTRACT
The paper provides a novel method for the reversible control of solubility by use of functionalized nanoparticles. The nanoparticles are functionalized with functional groups that can act as a co-solvent or anti-solvent and thus can induce either dissolution or crystallization. The process is reversible, as the solution will go back to its original state when the nanoparticles are removed. The use of magnetic nanoparticles facilitates this reversibility. Reductions in solubility (and thus crystallization) were demonstrated for d-mannitol-water, sodium chloride-water and fenofibrate-ethyl acetate systems. An increase in solubility (and thus dissolution) was demonstrated for the benzoic acid-water system and the 4-nitrophenol-water system. Reversible manipulation of solubility can be used to reduce solvent usage in dissolution and crystallization by elimination of the need for an antisolvent or co-solvent.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos