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The application of phenotypic microarray analysis to anti-fungal drug development.
Greetham, Darren; Lappin, David F; Rajendran, Ranjith; O'Donnell, Lindsay; Sherry, Leighann; Ramage, Gordon; Nile, Christopher.
Afiliación
  • Greetham D; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK.
  • Lappin DF; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
  • Rajendran R; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
  • O'Donnell L; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
  • Sherry L; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
  • Ramage G; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
  • Nile C; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: christopher.nile@glasgow.ac.uk.
J Microbiol Methods ; 134: 35-37, 2017 03.
Article en En | MEDLINE | ID: mdl-28082175
ABSTRACT
Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Acetilcolina / Análisis por Micromatrices / Descubrimiento de Drogas / Antifúngicos Idioma: En Revista: J Microbiol Methods Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Acetilcolina / Análisis por Micromatrices / Descubrimiento de Drogas / Antifúngicos Idioma: En Revista: J Microbiol Methods Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido