Association between long-term blood pressure control and ten-year progression in carotid arterial stiffness among hypertensive individuals: the multiethnic study of atherosclerosis.
J Hypertens
; 35(4): 862-869, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28092279
ABSTRACT
BACKGROUND:
Arterial stiffness was shown to be higher among hypertensive patients with diabetes than those without diabetes and among older than younger hypertensive patients. We examined whether the association between long-term blood pressure (BP) control and 10-year progression in carotid arterial stiffness varies by diabetes status and age.METHODS:
Participants were 906 individuals with hypertension at baseline and three follow-up visits in the Multi-Ethnic Study of Atherosclerosis (mean age 63.7 years, 44% males). Participants with SBP of less than 140âmmHg and DBP of less than 90âmmHg were considered to have a controlled BP. Arterial stiffness was measured using distensibility coefficientâ×â10/mmHg and Young's elastic modulus (YEMâ×â10âmmHg) at baseline and after a mean of 9.5 years (visit 5). Multiple linear regression model was used for the analysis.RESULTS:
Having controlled BP at three visits (distensibility coefficient ßâ=â3.6, Pâ=â0.004; YEM ßâ=â-6.8, Pâ=â0.07) or four visits (distensibility coefficient ßâ=â2.4, Pâ=â0.04; YEM ßâ=â-6.8, Pâ=â0.05), when compared with having uncontrolled BP at all four visit, was associated with lesser progression in arterial stiffness. In a stratified analysis, arterial stiffness progression was slower only among nondiabetics with controlled BP at three visits (distensibility coefficient ßâ=â4.3, Pâ=â0.002; YEM ßâ=â-8.8, Pâ=â0.04) or four visits (ßâ=â3.7, Pâ=â0.01; YEM ßâ=â-10.4, Pâ=â0.01) and among those less than 70 years with controlled BP at three visits (distensibility coefficient ßâ=â4.9, Pâ=â0.004; YEM ßâ=â-10.6, Pâ=â0.01) or four visits (distensibility coefficient ßâ=â2.9, Pâ=â0.07; YEM ßâ=â-7.6, Pâ=â0.03).CONCLUSION:
These findings suggest that controlling BP alone may not be sufficient to slow progression of arterial stiffness among hypertensive patients with concurrent diabetes and elderly hypertensive patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de las Arterias Carótidas
/
Aterosclerosis
/
Rigidez Vascular
/
Hipertensión
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Hypertens
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos