Iridium-Catalyzed Asymmetric Hydrogenation of Ketones with Accessible and Modular Ferrocene-Based Amino-phosphine Acid (f-Ampha) Ligands.
Org Lett
; 19(3): 690-693, 2017 02 03.
Article
en En
| MEDLINE
| ID: mdl-28093919
ABSTRACT
A series of tridentate ferrocene-based amino-phosphine acid (f-Ampha) ligands have been successfully developed. The f-Ampha ligands are extremely air stable and exhibited excellent performance in the Ir-catalyzed asymmetric hydrogenation of ketones (full conversions, up to >99% ee, and 500â¯000 TON). DFT calculations were performed to elucidate the reaction mechanism and the importance of the -COOH group. Control experiments also revealed that the -COOH group played a key role in this reaction.
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01-internacional
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MEDLINE
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En
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Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2017
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Article