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[Very Severe Differentiation Syndrome in Low Risk Acute Promyelocytic Leukemia - A Peril of Differentiating Therapy]. / Sehr schweres Differenzierungssyndrom bei Niedrigrisiko akuter Promyelozytenleukämie ­ eine Tücke der differenzierenden Therapie.
Hecht, Anna; Mezger, Joerg; Gnadler, Martina; Lengfelder, Eva.
Afiliación
  • Hecht A; Universitätsmedizin Mannheim, III. Medizinische Klinik, Hämatologie und internistische Onkologie, Mannheim.
  • Mezger J; St. Vincentius Kliniken, Abteilung für Hämatologie, Onkologie, Immunologie und Palliativmedizin, Karlsruhe.
  • Gnadler M; St. Vincentius Kliniken, Abteilung für Hämatologie, Onkologie, Immunologie und Palliativmedizin, Karlsruhe.
  • Lengfelder E; Universitätsmedizin Mannheim, III. Medizinische Klinik, Hämatologie und internistische Onkologie, Mannheim.
Dtsch Med Wochenschr ; 142(2): 111-114, 2017 Jan.
Article en De | MEDLINE | ID: mdl-28114716
History, examinations and diagnosis A young patient consulted the hospital because of spontaneous hematomas. The combination of pancytopenia and coagulopathy in the blood and the proving cytogenetic and moleculargenetic examinations of the bone marrow lead to the diagnosis of low-risk acute promyelocytic leukemia (APL). Therapy and clinical course During the combination therapy with ATRA and ATO, the patient developed a severe differentiation syndrome and hyperleukocytosis. Management of the condition was only possible due to clinical expertise and massive substitution of blood products and clotting factors. Conclusion The case illustrates the difficulty and dangers of APL induction therapy even with a favorable initial clinical presentation despite the generally low toxicity of new therapies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Promielocítica Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Disnea / Fiebre / Hipotensión / Enfermedades Pulmonares Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Idioma: De Revista: Dtsch Med Wochenschr Año: 2017 Tipo del documento: Article Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Promielocítica Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Disnea / Fiebre / Hipotensión / Enfermedades Pulmonares Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Idioma: De Revista: Dtsch Med Wochenschr Año: 2017 Tipo del documento: Article Pais de publicación: Alemania