[Evolution of subpopulations of cells of transplantable tumors following x-ray irradiation]. / Evoliutsiia subpopuliatsii kletok perevivaemykh opukholei posle rentgenovskogo oblucheniia.
Med Radiol (Mosk)
; 34(10): 65-9, 1989 Oct.
Article
en Ru
| MEDLINE
| ID: mdl-2811634
ABSTRACT
The paper is devoted to a study of the structure of subpopulations of 3 experimental tumors (ascitic Ehrlich carcinoma, melanoma B-16 and Lewis lung adenocarcinoma) in their progression and following single local X-radiation. At the same time some functional indices of cell viability were investigated over time intracellular pH, intensity of respiration, the level of cell protein, the level of lipid peroxidation (according to the content of one of its end-products--malonic dialdehyde). Considerable differences of subpopulations within one tumor and between different tumor types were established. The relationship of functional differences of these subpopulations with the clonogenicity of forming cells was shown. X-radiation caused inhomogeneous changes in the structure of subpopulations, the above indices changed. The authors have analyzed the regularity of these changes, their relationship with radiosensitivity or radioresistance of tumor cell subpopulations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Tumorales Cultivadas
/
Neoplasias Experimentales
Límite:
Animals
Idioma:
Ru
Revista:
Med Radiol (Mosk)
Año:
1989
Tipo del documento:
Article