Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer.
PLoS One
; 12(2): e0170942, 2017.
Article
en En
| MEDLINE
| ID: mdl-28152027
ABSTRACT
BACKGROUND:
Whether the characteristics and prognosis of gastric cancer (GC) are different in patients with and without Helicobacter pylori (HP) remains controversial. The definitions of HP status in patients with atrophic gastritis but negative tests for HP are heterogeneous. We aimed to assess the impact of HP on the prognosis of GC using different definitions.METHODS:
From 1998 Nov to 2011 Jul, five hundred and sixty-seven consecutive patients with GC were included. HP status was determined by serology and histology. Patients with any positive test were defined as HP infection. Patients without HP infection whose serum pepsinogen (PG) I <70 ng/dl and PG I/II ratio < 3.0 were defined as atrophic gastritis and they were categorized into model 1 HP positive; model 2 HP negative; and model 3 exclusion of these patients.RESULTS:
We found four characteristics of HP negative GC in comparison to HP positive GC (1) higher proportion of the proximal tumor location (24.0%, P = 0.004), (2) more diffuse histologic type (56.1%, p = 0.008), (3) younger disease onset (58.02 years, p = 0.008) and (4) more stage IV disease (40.6%, p = 0.03). Patients with negative HP had worse overall survival (24.0% vs. 35.8%, p = 0.035). In Cox regression models, the negative HP status is an independent poor prognostic factor (HR 1.34, CI1.04-1.71, p = 0.019) in model 1, especially in stage I, II and III patients (HR 1.62; CI1.05-2.51,p = 0.026).CONCLUSION:
We found the distinct characteristics of HP negative GC. The prognosis of HP negative GC was poor.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Adenocarcinoma
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Gastritis Atrófica
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Taiwán