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Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL.
Niu, Chi-Chien; Lin, Song-Shu; Yuan, Li-Jen; Chen, Lih-Huei; Yang, Chuen-Yung; Chung, An-Ni; Lu, Meng-Ling; Tsai, Tsung-Ting; Lai, Po-Liang; Chen, Wen-Jer.
Afiliación
  • Niu CC; Department of Orthopaedic, Chang Gung Memorial Hospital, Linkou, Taiwan. niuchien@adm.cgmh.org.tw.
  • Lin SS; College of Medicine, Chang Gung University, Taoyuan, Taiwan. niuchien@adm.cgmh.org.tw.
  • Yuan LJ; Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan. niuchien@adm.cgmh.org.tw.
  • Chen LH; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, No 5, Fu-Hsing Street 333, Taoyuan, Taiwan. niuchien@adm.cgmh.org.tw.
  • Yang CY; Department of Orthopaedic, Chang Gung Memorial Hospital, Linkou, Taiwan.
  • Chung AN; Department of Orthopaedic, Chang Gung Memorial Hospital, Linkou, Taiwan.
  • Lu ML; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Tsai TT; Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan.
  • Lai PL; Department of Orthopaedic, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • Chen WJ; Department of Orthopaedic, Chang Gung Memorial Hospital, Linkou, Taiwan.
BMC Musculoskelet Disord ; 18(1): 61, 2017 02 02.
Article en En | MEDLINE | ID: mdl-28153008
BACKGROUND: Wnt signaling plays an important role in development and maintenance of many organs and tissues. The most-studied secreted Wnt inhibitors are sclerostin (SOST), Dickkopf-related protein 1 (DKK-1), and secreted frizzled related protein 1 (SFRP-1) which play important roles in bone turnover. The present study investigated the relationship between serum Wnt inhibitors and diseases with excessive ossification structures, such as ossification of posterior longitudinal ligament (OPLL), ankylosing spondylitis (AS), diffuse idiopathic skeletal hyperostosis (DISH), and ossification of yellow ligament (OYL). METHODS: Twenty-five patients with AS, DISH, OPLL, or OYL were recruited in this study. Fasting peripheral blood samples were collected from all patients and nine controls. Various biomarkers of bone turnover including osteocalcin (OSC), osteoprotegerin (OPG), SFRP-1, DKK-1, and SOST were investigated. RESULTS: Our data showed that serum levels of OSC were higher, but Dkk-1 levels were lower in AS, DISH, OPLL, and OYL patients than those in the controls. Serum levels of SFRP-1 were significantly higher in DISH patients than those in the controls. Serum levels of SOST were significantly higher in DISH and OPLL patients than both levels in the controls. Serum levels of OPG were lower in AS patients than those in the controls. Serum levels of OSC were higher in the OPLL patients than those in the AS patients. Serum levels of DKK-1, SFRP-1, SOST, and OPG were not significantly different between the different disease groups. CONCLUSIONS: In this exploratory study, both OSC and DKK-1 levels are correlated with the clinical conditions associated with excessive ossification, indicating that blood OSC and DKK-1 levels may serve as diagnostic biomarkers for AS, DISH, OPLL, and OYL. These findings may also help discover potential drug therapies for management of these diseases in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Remodelación Ósea / Osificación del Ligamento Longitudinal Posterior / Hiperostosis Esquelética Difusa Idiopática / Proteínas Wnt Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Musculoskelet Disord Asunto de la revista: FISIOLOGIA / ORTOPEDIA Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Remodelación Ósea / Osificación del Ligamento Longitudinal Posterior / Hiperostosis Esquelética Difusa Idiopática / Proteínas Wnt Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Musculoskelet Disord Asunto de la revista: FISIOLOGIA / ORTOPEDIA Año: 2017 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido