Why do plants need so many cyclin-dependent kinase inhibitors?
Plant Signal Behav
; 12(2): e1282021, 2017 02.
Article
en En
| MEDLINE
| ID: mdl-28165885
ABSTRACT
Cell cycle regulation is fundamental to growth and development, and Cyclin-Dependent Kinase Inhibitors (CKIs) are major negative regulators of the cell cycle. Plant genomes encode substantially more CKIs than metazoan or fungal genomes. Plant CKIs fall into 2 distinct families, KIP-RELATED PROTEINS (KRPs) and SIAMESE-RELATED proteins (SMRs). SMRs can inhibit both S-phase and M-phase CDK complexes in vitro and are transcribed throughout the cell cycle, yet SMRs do not inhibit DNA replication in vivo. This suggests that SMRs must be activated post transcriptionally after the start of S-phase, but the mechanism of this hypothesized activation is unknown. Recent work indicates that even distantly related SMRs have the same biochemical function, and that differential transcriptional regulation likely maintains their distinct roles in integrating various environmental and developmental signals with the cell cycle.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Arabidopsis
/
Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina
Idioma:
En
Revista:
Plant Signal Behav
Asunto de la revista:
BOTANICA
/
FISIOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos