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Englerins: A Comprehensive Review.
Wu, Zhenhua; Zhao, Senzhi; Fash, David M; Li, Zhenwu; Chain, William J; Beutler, John A.
Afiliación
  • Wu Z; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
  • Zhao S; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
  • Fash DM; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
  • Li Z; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
  • Chain WJ; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
  • Beutler JA; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.
J Nat Prod ; 80(3): 771-781, 2017 03 24.
Article en En | MEDLINE | ID: mdl-28170253
In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos de Guayano / Neoplasias Renales / Antineoplásicos Fitogénicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Nat Prod Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos de Guayano / Neoplasias Renales / Antineoplásicos Fitogénicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Nat Prod Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos