Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study.

Smith, Clare M; Jerkovic, Ante; Truong, Thy Thuc; Foote, Simon J; McCarthy, James S; McMorran, Brendan J

Smith, Clare M; Jerkovic, Ante; Truong, Thy Thuc; Foote, Simon J; McCarthy, James S; McMorran, Brendan J.

Afiliación

Smith CM; School of Medicine and The Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia.
Jerkovic A; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
Truong TT; Joint Mass Spectrometry Facility, Research School of Chemistry, The Australian National University, Canberra, Australian Capital Territory, Australia.
Foote SJ; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
McCarthy JS; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
McMorran BJ; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

Sci Rep ; 7: 41975, 2017 02 08.

Article en En | MEDLINE | ID: mdl-28176804

Asunto(s)

Antifúngicos/uso terapéutico; Eritrocitos/parasitología; Ferroquelatasa/antagonistas & inhibidores; Griseofulvina/uso terapéutico; Malaria Falciparum/parasitología; Plasmodium falciparum/crecimiento & desarrollo; Adolescente; Adulto; Animales; Antifúngicos/metabolismo; Estudios de Casos y Controles; Estudios de Cohortes; Eritrocitos/efectos de los fármacos; Eritrocitos/metabolismo; Femenino; Estudios de Seguimiento; Griseofulvina/metabolismo; Humanos; Malaria Falciparum/tratamiento farmacológico; Malaria Falciparum/patología; Masculino; Persona de Mediana Edad; Proyectos Piloto; Plasmodium falciparum/efectos de los fármacos; Pronóstico; Adulto Joven

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Malaria Falciparum / Eritrocitos / Ferroquelatasa / Griseofulvina / Antifúngicos Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google