Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks.

Palermo, Valentina; Rinalducci, Sara; Sanchez, Massimo; Grillini, Francesca; Franchitto, Annapaola; Pichierri, Pietro

Palermo, Valentina; Rinalducci, Sara; Sanchez, Massimo; Grillini, Francesca; Franchitto, Annapaola; Pichierri, Pietro.

Afiliación

Palermo V; Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
Rinalducci S; Proteomics Laboratory, Department of Ecology and Biology, Università della Tuscia , Viterbo, Italy.
Sanchez M; Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità , Rome, Italy.
Grillini F; Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
Franchitto A; Section of Molecular Epidemiology, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
Pichierri P; Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.

Mol Cell Oncol ; 4(1): e1268243, 2017.

Article en En | MEDLINE | ID: mdl-28197541

RESUMEN

Replication-dependent double-strand breaks (DSBs) are the main source of genomic instability as their inaccurate repair stimulates chromosomal rearrangements. In a recent work, we uncover a novel regulatory circuit that involves the Werner's syndrome helicase and CDK1, and that is essential for repair pathway choice at replication-dependent DSBs.

Palabras clave

DNA repair; WRN protein; end-resection

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Cell Oncol Año: 2017 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

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