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Impaired white matter connectivity between regions containing mirror neurons, and relationship to negative symptoms and social cognition, in patients with first-episode schizophrenia.
Saito, Yukiko; Kubicki, Marek; Koerte, Inga; Otsuka, Tatsui; Rathi, Yogesh; Pasternak, Ofer; Bouix, Sylvain; Eckbo, Ryan; Kikinis, Zora; von Hohenberg, Christian Clemm; Roppongi, Tomohide; Del Re, Elisabetta; Asami, Takeshi; Lee, Sang-Hyuk; Karmacharya, Sarina; Mesholam-Gately, Raquelle I; Seidman, Larry J; Levitt, James; McCarley, Robert W; Shenton, Martha E; Niznikiewicz, Margaret A.
Afiliación
  • Saito Y; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Kubicki M; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
  • Koerte I; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA. kubicki@bwh.harvard.edu.
  • Otsuka T; VA Boston Healthcare System, Brockton Division, Brockton, MA, USA. kubicki@bwh.harvard.edu.
  • Rathi Y; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Pasternak O; Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
  • Bouix S; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Eckbo R; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Kikinis Z; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • von Hohenberg CC; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Roppongi T; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Del Re E; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Asami T; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Lee SH; Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Karmacharya S; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Mesholam-Gately RI; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Seidman LJ; Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany.
  • Levitt J; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • McCarley RW; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Shenton ME; Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, 1249 Street Boston, Boylston, MA, 02215, USA.
  • Niznikiewicz MA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Brain Imaging Behav ; 12(1): 229-237, 2018 02.
Article en En | MEDLINE | ID: mdl-28247157
ABSTRACT
In schizophrenia, abnormalities in structural connectivity between brain regions known to contain mirror neurons and their relationship to negative symptoms related to a domain of social cognition are not well understood. Diffusion tensor imaging (DTI) scans were acquired in 16 patients with first episode schizophrenia and 16 matched healthy controls. FA and Trace of the tracts interconnecting regions known to be rich in mirror neurons, i.e., anterior cingulate cortex (ACC), inferior parietal lobe (IPL) and premotor cortex (PMC) were evaluated. A significant group effect for Trace was observed in IPL-PMC white matter fiber tract (F (1, 28) = 7.13, p = .012), as well as in the PMC-ACC white matter fiber tract (F (1, 28) = 4.64, p = .040). There were no group differences in FA. In addition, patients with schizophrenia showed a significant positive correlation between the Trace of the left IPL-PMC white matter fiber tract, and the Ability to Feel Intimacy and Closeness score (rho = .57, p = 0.034), and a negative correlation between the Trace of the left PMC-ACC and the Relationships with Friends and Peers score (rho = remove -.54, p = 0.049). We have demonstrated disrupted white mater microstructure within the white matter tracts subserving brain regions containing mirror neurons. We further showed that such structural disruptions might impact negative symptoms and, more specifically, contribute to the inability to feel intimacy (a measure conceptually related to theory of mind) in first episode schizophrenia. Further studies are needed to understand the potential of our results for diagnosis, prognosis and therapeutic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Psicología del Esquizofrénico / Percepción Social / Encéfalo / Cognición / Sustancia Blanca Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Psicología del Esquizofrénico / Percepción Social / Encéfalo / Cognición / Sustancia Blanca Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos