First Report of the Carbapenemase Gene <i>bla</i><sub>OXA-499</sub> in Acinetobacter pittii.

D'Souza, Roshan; Pinto, Naina Adren; Higgins, Paul G; Hwang, Insik; Yong, Dongeun; Choi, Jongrak; Lee, Kyoungwon; Chong, Yunsop

First Report of the Carbapenemase Gene bla_OXA-499 in Acinetobacter pittii.

D'Souza, Roshan; Pinto, Naina Adren; Higgins, Paul G; Hwang, Insik; Yong, Dongeun; Choi, Jongrak; Lee, Kyoungwon; Chong, Yunsop.

Afiliación

D'Souza R; Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.
Pinto NA; Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.
Higgins PG; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, South Korea.
Hwang I; Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany, Germany.
Yong D; German Center for Infection Research (DZIF), Partner Site, Bonn-Cologne, Germany.
Choi J; Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.
Lee K; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, South Korea.
Chong Y; Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea deyong@yuhs.ac.

Antimicrob Agents Chemother ; 61(5)2017 05.

Article en En | MEDLINE | ID: mdl-28264850

RESUMEN

We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.

Asunto(s)

Infecciones por Acinetobacter/tratamiento farmacológico; Acinetobacter/genética; Antibacterianos/farmacología; Proteínas Bacterianas/genética; Carbapenémicos/farmacología; Resistencia betalactámica/genética; beta-Lactamasas/genética; Acinetobacter/efectos de los fármacos; Acinetobacter/aislamiento & purificación; Infecciones por Acinetobacter/microbiología; Anciano; ADN Bacteriano/genética; Humanos; Masculino; Pruebas de Sensibilidad Microbiana; Análisis de Secuencia de ADN

Palabras clave

Acinetobacter pittii; OXA-143-like; OXA-499; carbapenemase resistant

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Acinetobacter / Beta-Lactamasas / Infecciones por Acinetobacter / Carbapenémicos / Resistencia betalactámica / Antibacterianos Límite: Aged / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos

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