Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?
J Enzyme Inhib Med Chem
; 32(1): 683-687, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28274160
ABSTRACT
Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two ß-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the causative agent of brucellosis or Malta fever. These enzymes have been investigated in detail and a wide range of classical aromatic and heteroaromatic sulfonamides as well as carbohydrate-based compounds have been found to inhibit selectively and efficiently Brucella suis carbonic anhydrases. Inhibition of these metalloenzymes constitutes a novel approach for the potential development of new anti-Brucella agents. This review aims at discussing the recent literature on this topic.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfonamidas
/
Inhibidores de Anhidrasa Carbónica
/
Anhidrasas Carbónicas
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Brucella suis
/
Antibacterianos
Idioma:
En
Revista:
J Enzyme Inhib Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia