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Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
Wang, Aoli; Li, Xixiang; Wu, Hong; Zou, Fengming; Yan, Xiao-E; Chen, Cheng; Hu, Chen; Yu, Kailin; Wang, Wenchao; Zhao, Peng; Wu, Jiaxin; Qi, Ziping; Wang, Wei; Wang, Beilei; Wang, Li; Ren, Tao; Zhang, Shanchun; Yun, Cai-Hong; Liu, Jing; Liu, Qingsong.
Afiliación
  • Wang A; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Li X; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Wu H; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Zou F; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Yan XE; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Chen C; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Hu C; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Yu K; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang W; Department of Biophysics and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.
  • Zhao P; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wu J; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Qi Z; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang W; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Wang B; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang L; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Ren T; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Zhang S; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Yun CH; Department of Biophysics and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center , Beijing 100191, China.
  • Liu J; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Liu Q; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
J Med Chem ; 60(7): 2944-2962, 2017 04 13.
Article en En | MEDLINE | ID: mdl-28282122
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Carcinoma de Pulmón de Células no Pequeñas / Inhibidores de Proteínas Quinasas / Receptores ErbB / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Carcinoma de Pulmón de Células no Pequeñas / Inhibidores de Proteínas Quinasas / Receptores ErbB / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos