Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries.

An, Yuan-Ming; Feng, Han; Zhang, Xing-Zhong; Cong, Xin; Zhao, Qian; Wu, Li-Ling; Dou, Dou

An, Yuan-Ming; Feng, Han; Zhang, Xing-Zhong; Cong, Xin; Zhao, Qian; Wu, Li-Ling; Dou, Dou.

Afiliación

An YM; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Feng H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Zhang XZ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, Ch
Cong X; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, Ch
Zhao Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Wu LL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, Ch
Dou D; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China. Electronic address: doudou@bjmu.edu.cn.

Biochem Biophys Res Commun ; 486(1): 178-183, 2017 04 22.

Article en En | MEDLINE | ID: mdl-28285136

Asunto(s)

Fosfatidilinositol 3-Quinasa Clase Ia/metabolismo; Vasos Coronarios/efectos de los fármacos; Homocisteína/farmacología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal/efectos de los fármacos; Vasoconstricción/efectos de los fármacos; Animales; Western Blotting; Vasos Coronarios/metabolismo; Vasos Coronarios/fisiología; Relación Dosis-Respuesta a Droga; Endotelio Vascular/fisiología; Hipoxia; Técnicas In Vitro; Cadenas Ligeras de Miosina/metabolismo; Fosforilación/efectos de los fármacos; Subunidades de Proteína/metabolismo; Serina/metabolismo; Porcinos; Factores de Tiempo; Tirosina/metabolismo

Palabras clave

Akt kinase; Endothelium-independent hypoxic vasoconstriction; Homocysteine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasoconstricción / Transducción de Señal / Vasos Coronarios / Proteínas Proto-Oncogénicas c-akt / Fosfatidilinositol 3-Quinasa Clase Ia / Homocisteína Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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