Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells.
Anticancer Res
; 37(3): 1149-1159, 2017 03.
Article
en En
| MEDLINE
| ID: mdl-28314276
ABSTRACT
BACKGROUND/AIM:
Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities including vasodilatation, analgesia, anti-cardiovascular disease, anti-Alzheimer's disease, anti-inflammation, and anti-tumor activity. MATERIALS ANDMETHODS:
This study analyzes the anti-tumor effects of evodiamine on cellular growth, tumorigenesis, cell cycle and apoptosis induction of human urothelial cell carcinoma (UCC) cells.RESULTS:
The present study showed that evodiamine significantly inhibited the proliferation of UCC cells in a dose- and time-dependent manner. Also, evodiamine suppressed the tumorigenesis of UCC cells in vitro. Moreover, evodiamine caused G2/M cell-cycle arrest and induced caspase-dependent apoptosis in UCC cells. Finally, we demonstrated that evodiamine exhibits better cytotoxic than 5-fluorouracil, a clinical chemotherapeutic drug, for UCC cells.CONCLUSION:
Evodiamine induces growth inhibition, tumorigenesis suppression, cell-cycle arrest, and apoptosis induction in human UCC cells. Therefore, this agent displays a therapeutic potential for treating human UCC cells and is worthy for further investigation.Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Neoplasias de la Vejiga Urinaria
/
Carcinoma
/
Urotelio
/
Carcinogénesis
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2017
Tipo del documento:
Article