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The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.
Rudenko, Iakov N; Kaganovich, Alice; Langston, Rebekah G; Beilina, Aleksandra; Ndukwe, Kelechi; Kumaran, Ravindran; Dillman, Allissa A; Chia, Ruth; Cookson, Mark R.
Afiliación
  • Rudenko IN; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A. cookson@mail.nih.gov iakov.rudenko@stonybrookmedicine.edu.
  • Kaganovich A; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Langston RG; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Beilina A; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Ndukwe K; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Kumaran R; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Dillman AA; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Chia R; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.
  • Cookson MR; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A. cookson@mail.nih.gov iakov.rudenko@stonybrookmedicine.edu.
Biochem J ; 474(9): 1547-1558, 2017 04 24.
Article en En | MEDLINE | ID: mdl-28320779

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Predisposición Genética a la Enfermedad / Ubiquitina-Proteína Ligasas / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Mutación Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Biochem J Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Predisposición Genética a la Enfermedad / Ubiquitina-Proteína Ligasas / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Mutación Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Biochem J Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido